Importin Beta: Conducting a Much Larger Cellular Symphony

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• 作者：Amnon Harel and Douglass J. Forbes
• 刊名：Molecular Cell
• 出版年：2004
• 出版时间：5 November 2004
• 年：2004
• 卷：16
• 期：3
• 页码：319-330
• 全文大小：440 K

文摘

Importin β, once thought to be exclusively a nuclear transport receptor, is emerging as a global regulator of diverse cellular functions. Importin β acts positively in multiple interphase roles: in nuclear import, as a chaperone for highly charged nuclear proteins, and as a potential motor adaptor for movement along microtubules. In contrast, importin β plays a negative regulatory role in mitotic spindle assembly, centrosome dynamics, nuclear membrane formation, and nuclear pore assembly. In most of these, importin β is counteracted by its regulator, Ran-GTP. In light of this, the recent discovery of Ran's involvement in spindle checkpoint control suggested a potential new arena for importin β action, although it is also possible that one of importin β's relatives, the karyopherin family of proteins, manages this checkpoint. Lastly, importin β plays a role in transducing damage signals from the axons of injured neurons back to the cell body.