In vitro pharmacodynamic evaluation of ceftolozane/tazobactam against β-lactamase-producing Escherichia coli in a hollow-fibre infection model

详细信息    查看全文

• 作者：Rachel L. Soon^a ; Justin R. Lenhard^a ; ^b ; ^c ; Zackery P. Bulman^a ; ^b ; Patricia N. Holden^a ; ^b ; Pamela Kelchlin^a ; Judith N. Steenbergen^d ; Lawrence V. Friedrich^d ; Alan Forrest^a ; ^b ; Brian T. Tsuji^a ; ^b ; ^{btsuji@buffalo.edu}
• 关键词：Ceftolozane/tazobactam ; Escherichia coli ; β-Lactamase ; AmpC ; CMY-10 ; CTX-M-15
• 刊名：International Journal of Antimicrobial Agents
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：49
• 期：1
• 页码：25-30
• 全文大小：573 K
• 卷排序：49

文摘

Ceftolozane/tazobactam is highly active against certain Escherichia coli strains. Diminished activity was observed against a CTX-M-15-producing strain (MICTAZ4 = 8 mg/L). Rapid bactericidal activity against AmpC- and CMY-10-producing strains was detected.