Bisphenol A induces hypothalamic down-regulation of the the cannabinoid receptor 1 and anorexigenic effects in male mice

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• 作者：Antonio Suglia^a ; Rosanna Chianese^a ; Marina Migliaccio^a ; Concetta Ambrosino^b ; ^c ; Silvia Fasano^a ; Riccardo Pierantoni^a ; ^{riccardo.pierantoni@unina2.it" class="auth_mail" title="E-mail the corresponding author} ; Gilda Cobellis^a ; ¹ ; Teresa Chioccarelli^a ; ¹
• 关键词：2-AG ; 2-arachidonoylglycerol ; AT ; adipose tissue ; AgRP ; agouti-related protein ; AEA ; anandamide ; ARC ; arcuate nucleus ; ArKO ; aromatase knock-out ; BPA ; bisphenol A ; BAT ; brown adipose tissues ; CB1 ; cannabinoid receptor 1 ; CART ; cocaine and amphetamine-regulated transcript ; eWAT ; epididymal white adipose tissues ; αERK ; Oestrogen receptor alpha knock-out ; ERα ; estrogen receptor alpha ; ERβ ; estrogen receptor beta ; ERRγ ; estrogen-related receptor gamma ; Faah ; fatty acid amide hydrolase ; Gpr54 ; G prot
• 刊名：Pharmacological Research
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：113
• 期：part_PA
• 页码：376-383
• 全文大小：951 K

文摘

Bisphenol A is an environment-polluting industrial chemical able to interfere with the endocrine system. An obesogenic effect in perinatally exposed rodents has been described as estrogenic activity. We exposed male mice to Bisphenol A during fetal-perinatal period (from 10 days post coitum to 31 days post partum) and investigated the effects of this early-life exposure at 78 days of age. Body weight, food intake, fat mass, and hypothalamic signals related to anorexigenic control of food intake were analyzed. Results show that Bisphenol A exposure reduced body weight and food intake. In addition, the exposure decreased epididymal fat mass and adiposity, acting negatively on adipocyte volume. At hypothalamic level, Bisphenol A exposure reduced the expression of the cannabinoid receptor 1 and induced gene expression of cocaine and amphetamine-regulated transcript-1. This observation suggests that Bisphenol A induces activation of anorexigenic signals via down-regulation of the hypothalamic cannabinoid receptor 1 with negative impact on food intake.