文摘
Cardenolides and bufadienolides present similar mechanism of Na+/K+-ATPase inhibition. Bufadienolides show moderate selectivity against human tumor cells and weak activity on murine cells. Bufalin, cinobufagin, telocinobufagin and marinobufagin exhibited remarkable antitumor potential triggered by caspase-dependent apoptosis. Bufalin or Cinobufagin have been used in clinical therapy against advanced carcinomas of liver, lung, pancreas and bladder.