MYCN controls an alternative RNA splicing program in high-risk metastatic neuroblastoma
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- 作者：Shile Zhanga ; b ; 1 ; Jun S. Weia ; 1 ; Samuel Q. Lia ; Tom C. Badgetta ; c ; Young K. Songa ; Saurabh Agarwald ; Cristian Coarfad ; Catherine Tolmana ; Laura Hurda ; Hongling Liaoa ; Jianbin Hea ; Xinyu Wena ; Zhihui Liue ; Carol J. Thielee ; Frank Westermannf ; Shahab Asgharzadehg ; h ; i ; Robert C. Seegerg ; h ; i ; John M. Marisj ; k ; l ; m ; Jamie M. Guidry Auviln ; Malcolm A. Smitho ; Eric D. Kolaczykb ; p ; Jason Shohetd ; Javed Khana ; khanjav@mail.nih.gov" class="auth_mail" title="E-mail the corresponding author
- 关键词：NBL ; neuroblastoma ; pre-mRNA ; pre-messenger RNA ; MYCN-A ; MYCN-amplified ; MYCN-NA ; MYCN-not-amplified ; RNA-seq ; RNA sequencing ; PCA ; principle component analysis ; DEG ; differentially expressed genes ; DSG ; differentially spliced genes ; ChIP-seq ; Chromatin Immunoprecipitation sequencing
- 刊名：Cancer Letters
- 出版年：2016
- 出版时间：28 February 2016
- 年：2016
- 卷：371
- 期：2
- 页码：214-224
- 全文大小：2453 K
文摘
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A characteristic isoform expression pattern is detected in MYCN-amplified NBL tumors.
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Several splicing factors control the splicing program in NBL tumors.
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MYCN directly controls the expression of splicing factors PTBP1 and HNRNPA1.
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Splicing factors PTBP1 and HNRNPA1 and their downstream splicing target PKM2 affect MYCN-amplified NBL cell proliferation.