WT1 expression is inversely correlated with MYCN amplification or expression and associated with poor survival in non-MYCN-amplified neuroblastoma
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- 作者：Caroline Masserota ; b ; Qingyuan Liua ; b ; Eric Nguyena ; b ; Charles-Henry Gattolliatc ; d ; Dominique Valteau-Couanete ; Jean Bé ; nardc ; d ; Catherine Huberf ; g ; Evelyne Sé ; gal-Bendirdjiana ; b ; evelyne.segal-bendirdjian@inserm.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Neuroblastoma ; Differentiation ; Wilms' tumors ; MYCN
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：10
- 期：2
- 页码：240-252
- 全文大小：829 K
文摘
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An inverse correlation between WT1 and MYCN expressions is revealed in neuroblastoma (NB).
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High expression of WT1 is associated with lower survival in non-MYCN-amplified NB.
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Flat and substrate-adherent NB cells express high levels of WT1.
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WT1 is potentially a prognostic marker in NB without MYCN amplification.