Integration of in silico modeling, prediction by binding energy and experimental approach to study the amorphous chitin nanocarriers for cancer drug delivery
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- 作者：P. Geetha1 ; Amal J. Sivaram1 ; R. Jayakumar ; rjayakumar@aims.amrita.edu" class="auth_mail" title="E-mail the corresponding author ; jayakumar77@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; C. Gopi Mohan ; cgmohan@aims.amrita.edu" class="auth_mail" title="E-mail the corresponding author ; cgopimohan@yahoo.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Chitin nanoparticles ; Curcumin/5-fluorouracil/docetaxel ; Drug-delivery ; Polymer&ndash ; drug interactions ; Binding energy
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 May 2016
- 年：2016
- 卷：142
- 期：Complete
- 页码：240-249
- 全文大小：2739 K
文摘
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Curcumin, docetaxel, 5-FU loaded amorphous chitin nanoparticles was prepared.
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Curcumin drug showed as best carrier for amorphous chitin nanoparticles (AC-NPs).
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Cytotoxicity and cellular uptake was studied on Gastric cancer cells.
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In silico binding energy (BE) between AC-NPs and anti-cancer drugs were studied.
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Computational BEs correlates with experimental loading and entrapment efficiencies.