文摘
Aβ42 is oxidized via Tyr, His, and Met residues at carbon SPE. Aβ42 Met-35 residue oxidation produces a broad wave at about 1.2–1.5 V (vs. Ag/AgCl). Ser-8 phosphorylation affects the Aβ42 signal at about 1.2–1.5 V (vs. Ag/AgCl). Oxidation is sensitive to amino acid substitutions in the Aβ42 peptide, such as D7H. Upon the aggregation of Aβ42 and its isoforms, the Tyr, His, and Met oxidation signals decrease.