Reaction between the Pt(II)-complexes and the amino acids of the β-amyloid peptide

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• 作者：Willian T.G. Novato^a ; Pedro Henrique F. Stroppa^b ; Adilson D. Da Silva^b ; Naiara P. Botezine^c ; Flá ; via C. Machado^c ; Luiz Antô ; nio S. Costa^a ; Hé ; lio F. Dos Santos^a ; ^{helio.santos@ufjf.edu.br}
• 关键词：Pt(II)-complexes ; Alzheimer ; Amyloid ; DFT
• 刊名：Chemical Physics Letters
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：667
• 期：Complete
• 页码：4-8
• 全文大小：828 K
• 卷排序：667

文摘

The reaction of two Pt(II) complexes with several amino acids are analyzed. All amino acids used as targets are present in the b-amyloid peptide. The reactivity order is driven by thermodynamics with N-containing residues found the main targets.