Membrane effects of dihydropyrimidine analogues with larvicidal activity

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• 作者：Mariela E. Sá ; nchez-Borzone^a ; ¹ ; Maria E. Mariani^a ; ¹ ; Virginia Miguel^a ; ¹ ; Raquel M. Gleiser^b ; Bharti Odhav^c ; Katharigatta N. Venugopala^c ; Daniel A. Garcí ; a^a ; ^{dagarcia@unc.edu.ar} ; ^{dasmedgarcia@yahoo.com}
• 关键词：Dihydropyrimidine ; Larvicidal ; Membrane interaction ; Monolayers ; Membrane fluidity ; Molecular dynamic simulations
• 刊名：Colloids and Surfaces B: Biointerfaces
• 出版年：2017
• 出版时间：1 February 2017
• 年：2017
• 卷：150
• 期：Complete
• 页码：106-113
• 全文大小：1636 K
• 卷排序：150

文摘

The interaction of two insecticidal dihydropyrimidines with membranes was studied. DHPMs penetrate into membranes at naturally occurring molecular pressures. DHPMs partition into membranes diminishes the bilayer fluidity. DHPMs interact with the polar region of the bilayer. MD simulations showed a favorable partition of DHPM at carbonyl moiety of lipids.