Immune-modifying properties of topical vitamin D: Focus on dendritic cells and T cells

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• 作者：Shelley Gorman ; Melinda A. Judge ; Prue H. Hart
• 关键词：Vitamin D ; Skin ; Skin-draining lymph nodes ; Dendritic cells ; T cells
• 刊名：The Journal of Steroid Biochemistry and Molecular Biology
• 出版年：2010
• 出版时间：July 2010
• 年：2010
• 卷：121
• 期：1-2
• 页码：247-249
• 全文大小：216 K

文摘

Topical creams containing the active form of vitamin D (1,25-dihydroxyvitamin D₃; 1,25(OH)₂D₃) or analogues of this compound are currently used with some success to treat skin conditions including psoriasis and vitiligo. As well as targeting inflammatory processes in the skin, topical application of 1,25(OH)₂D₃ also affects the function of immune cells in the skin and draining lymph nodes. Topically applied 1,25(OH)₂D₃ reduces the number of dendritic cells in the skin, resulting in suppressed immunity and in particular reduced contact hypersensitivity (CHS) responses. Topical 1,25(OH)₂D₃ may also promote the migration of dendritic cells from the skin to the draining lymph nodes. Skin application of 1,25(OH)₂D₃ prevented the inflammatory effects of UVB irradiation on lymph node hypertrophy, when cell numbers were examined 4 days after skin treatment. In contrast, when 1,25(OH)₂D₃ was applied to UVB irradiated skin, there was no reversal in the suppression of CHS responses caused by UVB irradiation. Instead, 1,25(OH)₂D₃ had an additive effect with UVB to suppress CHS responses to a greater degree than UVB alone. In these studies, 1,25(OH)₂D₃ was applied to the treated skin of BALB/c mice immediately following UVB irradiation. Finally, topical 1,25(OH)₂D₃ also enhanced the number and suppressive activity of CD4+CD25+ regulatory T cells in the lymphatic tissue draining skin.