Measuring the sticking of mefenamic acid powders on stainless steel surface

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• 作者：Zihua Wang^a ; Umang V. Shah^a ; Dolapo Olusanmi^b ; Ajit S. Narang^b ; Munir A. Hussain^b ; John F. Gamble^c ; Michael J. Tobyn^c ; Jerry Y.Y. Heng^a ; ^{jerry.heng@imperial.ac.uk" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Adhesion quantification ; Sticking ; Surface roughness ; Optical profilometer ; HPLC
• 刊名：International Journal of Pharmaceutics
• 出版年：2015
• 出版时间：30 December 2015
• 年：2015
• 卷：496
• 期：2
• 页码：407-413
• 全文大小：2626 K

文摘

This study proposes an approach for quantifying the amount of pharmaceutical powder adhering (quality attribute) to the metals surfaces. The effect of surface roughness (detrimental attribute) on the amount of powder sticking to a stainless steel surface for a model pharmaceutical material is also qualitatively determined. Methodology to quantify powder adhesion to surfaces utilises a texture analyser and HPLC. The approach was validated to qualitatively investigate effect of metal surface roughness on adhesion of mefenamic acid. An increase in metal surface roughness resulted in an increase in cohesion. By increasing the average roughness from 289 nm to 407 nm, a 2.5 fold increase in amount adhering to metal was observed, highlighting the role of surface roughness on adhesion. The simplicity in experimental design with no requirement of specialised equipment and operational ease makes the approach very easy to adopt. Further, ease in interpreting results makes this methodology very attractive.