Task-related fMRI responses to a nicotinic acetylcholine receptor partial agonist in schizophrenia: A randomized trial
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- 作者：Deanna M. Barcha ; c ; i ; dbarch@wustl.edu" class="auth_mail" title="E-mail the corresponding author ; Stephen R. Marderb ; j ; SMarder@mednet.ucla.edu" class="auth_mail" title="E-mail the corresponding author ; Michael P. Harmsc ; mharms@wustl.edu" class="auth_mail" title="E-mail the corresponding author ; L. Fredrik Jarskogd ; lars_jarskog@med.unc.edu" class="auth_mail" title="E-mail the corresponding author ; Robert W. Buchanane ; rwbuchanan@mprc.umaryland.edu" class="auth_mail" title="E-mail the corresponding author ; Will Cronenwettf ; w-cronenwett@northwestern.edu" class="auth_mail" title="E-mail the corresponding author ; Li-Shiun Chenc ; chenli@psychiatry.wustl.edu" class="auth_mail" title="E-mail the corresponding author ; Markus Weissg ; markus.weiss@novartis.com" class="auth_mail" title="E-mail the corresponding author ; Ralph P. Maguireg ; paul.maguire@novartis.com" class="auth_mail" title="E-mail the corresponding author ; Nicole Pezousg ; nicole.pezous@novartis.com" class="auth_mail" title="E-mail the corresponding author ; Dominik Feuerbachg ; dominik.feuerbach@novartis.com" class="auth_mail" title="E-mail the corresponding author ; Cristina Lopez-Lopezg ; cristina.lopez_lopez@novartis.com" class="auth_mail" title="E-mail the corresponding author ; Donald R. Johnsg ; donald.johns@biogen.com" class="auth_mail" title="E-mail the corresponding author ; Rhett B. Behrjeg ; rhett.behrje@novartis.com" class="auth_mail" title="E-mail the corresponding author ; Baltazar Gomez-Mancillag ; h ; baltazar.gomezmancilla@novartis.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AE ; Adverse event ; ant. ; Anterior ; ASL ; Arterial Spin Labeling ; BOLD ; Blood-oxygenation-level dependent ; CBF ; Cerebral blood flow ; CI ; Confidence interval ; CYP ; Cytochrome P450 ; DOF ; Degree of freedom ; EMT ; Episodic memory task ; EV ; Explanatory variables ; fBIRN ; Functional Bioinformatics Research Network ; FEAT ; fMRI Expert Analysis Tool ; fMRI ; Functional magnetic resonance imaging ; FSL ; Functional Software Library ; GLM ; General Linear Modeling ; Hippo. ; Hippocampus ; MCCB ; MATRICS Consensus Cognit
- 刊名：Progress in Neuropsychopharmacology & Biological Psychiatry
- 出版年：2016
- 出版时间：3 November 2016
- 年：2016
- 卷：71
- 期：Complete
- 页码：66-75
- 全文大小：504 K
文摘
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Randomized, double-blind, placebo-controlled imaging study in schizophrenia
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Performance of working and episodic memory tasks associated with brain activation
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AQW051 (7.5 mg) associated with significant effects on episodic memory vs placebo
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AQW051 did not significantly improve working memory in study participants.
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AQW051 was well tolerated with an acceptable safety profile.