Flow-through cross-polarized imaging as a new tool to overcome the analytical sensitivity challenges of a low-dose crystalline compound in a lipid matrix
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- 作者：Camille Adlera ; b ; Monica Schö ; nenbergerc ; Alexandra Telekid ; Bruno Leuenbergerd ; Martin Kuentza ; martin.kuentz@fhnw.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：Solid lipid formulations ; Crystalline active compound ; Analytical tools ; Sensitivity limits ; Sampling issues ; Flow-through cross-polarized imaging
- 刊名：Journal of Pharmaceutical and Biomedical Analysis
- 出版年：2015
- 出版时间：10 November 2015
- 年：2015
- 卷：115
- 期：Complete
- 页码：20-30
- 全文大小：3765 K
文摘
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Beta-carotene in a lipid matrix was analyzed by means of XRPD and Hyper-DSC.
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Different microscopic techniques were compared: AFM, PLM, 3D-laser profiling.
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The previous methods demonstrated issues of sampling and sensitivity.
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A new flow-through cross-polarized light imaging technique was introduced.
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The novel tool enabled a robust detection of already a few crystalline particles.