Analytical challenges in breath analysis and its application to exposure monitoring

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• 作者：Mò ; nica Alonso ; Juan M. Sanchez ; ^{juanma.sanchez@udg.edu}
• 关键词：Breath analysis ; Environmental pollutant ; Exposure ; Human physiology ; Monitoring ; Sample collection ; Sample enrichment ; Solid-phase microextraction (SPME) ; Toxic substance ; Volatile organic compound (VOC)
• 刊名：TrAC Trends in Analytical Chemistry
• 出版年：2013
• 出版时间：March, 2013
• 年：2013
• 卷：44
• 期：Complete
• 页码：78-89
• 全文大小：558 K

文摘

There is an increasing interest in the use of breath analysis for monitoring human physiology and exposure to toxic substances or environmental pollutants.

This review focuses on the current status of the sampling procedures, collection devices and sample-enrichment methodologies used for exhaled breath-vapor analysis. We discuss the different parameters affecting each of the above steps, taking into account the requirements for breath analysis in exposure assessments and the need to analyze target compounds at sub-ppbv levels.

Finally, we summarize the practical applications of exposure analysis in the past two decades.