Polyketide Quinones Are Alternate Intermediate Electron Carriers during Mycobacterial Respiration in Oxygen-Deficient Niches
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- 作者：Amitesh Anand1 ; 2 ; 11 ; Priyanka Verma3 ; 11 ; Anil Kumar Singh4 ; Sandeep Kaushik1 ; Rajesh Pandey1 ; Ce Shi5 ; Harneet Kaur6 ; Manbeena Chawla7 ; Chandra Kumar Elechalawar2 ; 8 ; Dhirendra Kumar1 ; Yong Yang9 ; Neel S. Bhavesh10 ; Rajkumar Banerjee2 ; 8 ; Debasis Dash1 ; Amit Singh7 ; Vivek T. Natarajan1 ; Anil K. Ojha9 ; Courtney C. Aldrich5 ; 6 ; Rajesh S. Gokhale1 ; 2 ; 3 ; rsg@igib.res.in" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2015
- 出版时间：19 November 2015
- 年：2015
- 卷：60
- 期：4
- 页码：637-650
- 全文大小：4739 K
文摘
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Mycobacterial biofilm contains physiologically diverse microenvironments
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Hypoxia induces expression of the alternate electron carrier polyketide quinones
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PkQs are produced by type III polyketide synthases using fatty acyl-CoA precursors
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PkQs maintain cellular bioenergetics in oxygen-deficient niches