Efficacy of Hyalomma scupense (Hd86) antigen against Hyalomma excavatum and H. scupense tick infestations in cattle

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• 作者：Yousr Galaï ; ^a ; ^{yousr.galai@pasteur.rns.tn} ; Mario Canales^b ; Mourad Ben Saï ; d^a ; Mohamed Gharbi^a ; Moez Mhadhbi^a ; Mohamed Jedidi^a ; José ; de La Fuente^b ; ^c ; Mohamed-Aziz Darghouth^a
• 关键词：Rhipicephalus microplus ; Hyalomma scupense ; Hyalomma excavatum ; Bm86 vaccine ; Hd86 vaccine
• 刊名：Vaccine
• 出版年：2012
• 出版时间：19 November, 2012
• 年：2012
• 卷：30
• 期：49
• 页码：7084-7089
• 全文大小：272 K

文摘

The Rhipicephalus microplus recombinant Bm86-based tick vaccines have shown their efficacy for the control of several Hyalomma cattle ticks genera, namely H. dromedarii and H. anatolicum. However, H. scupense species, the most important tick in North Africa has never been studied. Vaccination trials using either a recombinant Bm86-based vaccine or a recombinant Hd86-based vaccine (the Bm86 ortholog in H. scupense) were conducted in cattle against immature and adult H. scupense ticks and adult H. excavatum ticks. The results showed a 59.19 % reduction in the number of scupense nymphs engorging on Hd86 vaccinated cattle. However, cattle vaccination with Bm86 or Hd86 did not have an effect on H. scupense or H. excavatum adult ticks infestations. These results showed that Hd86 vaccines are selectively effective against H. scupense immature instars and emphasize on an integrated anti-tick vaccine control in North Africa.