Palmitoylation in Alzheimer’s disease and other neurodegenerative diseases

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• 作者：Eunsil Cho^a ; ^b ; Mikyoung Park^a ; ^b ; ^{mikyoungpark7@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; ^{mpark@kist.re.kr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：ABCA1 ; ATP-binding cassette transporter A1 ; AD ; Alzheimer&rsquo ; s disease ; ADAM17 ; a disintegrin and metalloproteinase 17 ; AICD ; APP intracellular domain ; AKAP79 ; A-kinase anchoring protein 79 ; AMPA ; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate ; APP ; amyloid precursor protein ; APT ; acyl protein thioesterase ; BACE1 ; β-site APP cleaving enzyme 1 ; CI-MPR ; cation-independent mannose 6-phosphate receptor ; CKAP4 ; cytoskeleton-associated protein 4 ; CLL ; chronic lymphocytic leukemia ; CNS ; central ne
• 刊名：Pharmacological Research
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：111
• 期：Complete
• 页码：133-151
• 全文大小：3224 K

文摘

Posttranslational modifications of proteins are important regulatory processes endowing the proteins functional complexity. Over the last decade, numerous studies have shed light on the roles of palmitoylation, one of the most common lipid modifications, in various aspects of neuronal functions. Major players regulating palmitoylation are the enzymes that mediate palmitoylation and depalmitoylation which are palmitoyl acyltransferases (PATs) and protein thioesterases, respectively. In this review, we will provide and discuss current understandings on palmitoyation/depalmitoylation control mediated by PATs and/or protein thioesterases for neuronal functions in general and also for Alzheimer’s disease in particular, and other neurodegenerative diseases such as Huntington’s disease, schizophrenia and intellectual disability.