Emerging roles of A-kinase anchoring proteins in cardiovascular pathophysiology
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- 作者：Dario Diviani ; Dario.diviani@unil.ch" class="auth_mail" title="E-mail the corresponding author ; Erica Reggi ; Miroslav Arambasic ; Stefania Caso ; Darko Maric
- 关键词：A kinase anchoring protein (AKAP) ; Protein kinase A (PKA) ; Signaling ; Cardiac remodeling ; Cardiomyocyte ; Vascular smooth muscle cells
- 刊名：Biochimica et Biophysica Acta (BBA)-Molecular Cell Research
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：1863
- 期：7
- 页码：1926-1936
- 全文大小：1778 K
文摘
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A-kinase anchoring proteins (AKAPs) assemble multifunctional signaling complexes in cells.
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AKAPs coordinate signaling cascades that regulate cardiac and vascular functions.
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We analyze recent literature describing the role of AKAPs in cardiovascular pathophysiology.
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We discuss how AKAPs control vascular integrity, blood pressure and cardiac remodeling.