Clustering and Functional Coupling of Diverse Ion Channels and Signaling Proteins Revealed by Super-resolution STORM Microscopy in Neurons
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- 作者：Jie Zhang1 ; Chase M. Carver1 ; Frank S. Choveau1 ; Mark S. Shapiro1 ; 2 ; shapirom@uthscsa.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：super-resolution microscopy ; ion channels ; A-kinase anchoring proteins ; potassium channels
- 刊名：Neuron
- 出版年：2016
- 出版时间：19 October 2016
- 年：2016
- 卷：92
- 期：2
- 页码：461-478
- 全文大小：6414 K
文摘
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Intimate protein complex associations were identified using super-resolution imaging
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CaV1.2 channels form multi-channel supercomplexes with AKAP150 in sensory neurons
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Multi-channel supercomplexes are observed between different types of ion channels
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AKAP150 is required for the formation and function of the supercomplexes