Arginine Methylation: The Coming of Age

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• 作者：Romé ; o S. Blanc¹ ; ² ; Sté ; phane Richard¹ ; ² ; ^{stephane.richard@mcgill.ca}
• 关键词：PRMT1 ; PRMT5 ; arginine ; methylation ; epigenetic ; methyltransferase ; post-translational modification ; methylarginine ; demethylase ; and S-adenosyl-methionine
• 刊名：Molecular Cell
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：65
• 期：1
• 页码：8-24
• 全文大小：3756 K
• 卷排序：65

文摘

Arginine methylation is a common post-translational modification functioning as an epigenetic regulator of transcription and playing key roles in pre-mRNA splicing, DNA damage signaling, mRNA translation, cell signaling, and cell fate decision. Recently, a wealth of studies using transgenic mouse models and selective PRMT inhibitors helped define physiological roles for protein arginine methyltransferases (PRMTs) linking them to diseases such as cancer and metabolic, neurodegenerative, and muscular disorders. This review describes the recent molecular advances that have been uncovered in normal and diseased mammalian cells.