ATP leakage induces P2XR activation and contributes to acute synaptic excitotoxicity induced by soluble oligomers of 尾-amyloid peptide in hippocampal neurons
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- 作者：F. Sá ; ez-Orellanaa ; P.A. Godoya ; C.Y. Bastidasa ; T. Silva-Grecchia ; L. Guzmá ; nb ; L.G. Aguayob ; J. Fuentealbaa ; c ; jorgefuentealba@udec.cl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Alzheimer's disease ; ATP ; P2X receptors ; A尾 peptide oligomer
- 刊名：Neuropharmacology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：100
- 期：Complete
- 页码：116-123
- 全文大小：1468 K
文摘
A尾 increases extracellular ATP causing activation of P2X receptors.
ATP leakage contributes to acute synaptic excitotoxicity.
A尾 induces excitotoxicity by binding preferentially to excitatory neuron.
The effects were blocked by a non-specific P2XR antagonist.
The neurotoxicity of A尾 is mediated by P2XR activation.