Schizophrenia risk variants affecting microRNA function and site-specific regulation of NT5C2 by miR-206
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- 作者：Mads Engel Hauberga ; b ; c ; 1 ; hauberg@biomed.au.dk" class="auth_mail" title="E-mail the corresponding author ; Marie Hebsgaard Holm-Nielsena ; 1 ; Manuel Mattheisena ; b ; c ; Anne Louise Askoua ; Jakob Grovea ; b ; c ; d ; Anders Dupont Bø ; rgluma ; b ; c ; Thomas Juhl Corydona ; corydon@biomed.au.dk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Schizophrenia ; Genome-wide association study ; MicroRNA ; Single nucleotide polymorphism ; miR-206 ; and NT5C2
- 刊名：European Neuropsychopharmacology
- 出版年：2016
- 出版时间：September 2016
- 年：2016
- 卷：26
- 期：9
- 页码：1522-1526
- 全文大小：462 K
文摘
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Several schizophrenia risk variants affecting microRNA function are identified.
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One genome-wide significant variant, disrupts the binding of miR-206 to NT5C2.
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Experimental follow-up support this schizophrenia protective variant.