Nucleoside transport inhibition in ischemic myocardium results in enhanced taurine efflux

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• 作者：Zemgulis ; Vitas ; Wikstr&ouml ; m ; Gerhard ; Henze ; Axel ; Waldenstr&ouml ; m ; Anders ; Thelin ; Stefan ; et. al.
• 关键词：Myocardial infarction ; Nucleoside transport ; Adenosine ; Taurine ; Dipyridamole
• 刊名：European Journal of Pharmacology
• 出版年：2001
• 出版时间：May, 2001
• 年：2001
• 卷：411
• 期：1-2
• 页码：143-154
• 全文大小：478 K

文摘

We measured with the microdialysis technique energy-related metabolites in ischemic myocardium over time in an experimental pig model. Emphasis was put on the dipyridamole effect when administered in the microdialysis probe inserted in ischemic myocardium. Not only adenosine but also taurine and pyruvate concentrations were significantly higher in the microdialysate during the periods of ischemia and extracorporeal circulation with cardioplegia. The enhanced efflux of taurine in ischemic myocardium induced by dipyridamole is a new finding. A mechanistic role of taurine in the prevention of Ca²⁺ overload in ischemic myocytes is discussed. Also, taurine may have stimulatory effects on glycolysis in ischemic heart.