Reticular angiomatoid “malignant” fibrous histiocytoma—a case report with cytogenetics and molecular genetic analyses

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• 作者：Rafael D. Moura MD<sup>asup> ; Xiaoke Wang MS<sup>bsup> ; Melissa L. Lonzo MS<sup>bsup> ; Michele R. Erickson-Johnson MS<sup>bsup> ; Joaqu&#xed ; n J. Garc&#xed ; a MD<sup>bsup> ; Andre M. Oliveira MD<sup>bsup><sup> ; sup><sup>oliveira.andre@mayo.edu"" rel=""nofollowsup>
• 关键词：Angiomatoid “ ; malignant” ; fibrous histiocytoma ; Mediastinum ; EWSR1 ; CREB1
• 刊名：Human Pathology
• 出版年：2011
• 出版时间：September 2011
• 年：2011
• 卷：42
• 期：9
• 页码：1359-1363
• 全文大小：1159 K

文摘

ss=""h3"">Summary

Angiomatoid “malignant” fibrous histiocytoma is a rare sarcoma of low malignant potential that occurs most commonly in the extremities of children and young adults. Herein, we present a case of angiomatoid malignant fibrous histiocytoma with unusual histologic features arising in the mediastinum of an 80-year-old man. The tumor exhibited a reticular growth pattern and myxoid stroma. The tumor cells expressed epithelial membrane antigen and desmin. Cytogenetic analysis revealed the translocation t(2;22)(q33;q12). Molecular genetic analysis confirmed the rearrangement of the EWSR1 locus and the presence of the EWSR1/CREB1 fusion. This report expands the clinicopathologic spectrum of angiomatoid malignant fibrous histiocytoma and underscores the value of integrating morphologic, immunophenotypic, and molecular findings in the identification of its unusual morphologic variants.