Combined effects of coenzyme Q₁₀ and Vitamin E in cadmium induced alterations of antioxidant defense system in the rat heart

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• 作者：Branka I. Ognjanović ; Sne&#x17e ; ana D. Marković ; Sladjan Z. Pavlović ; Radoslav V. &#x17d ; ikić ; Andraš ; Š ; . Š ; tajn and Zorica S. Saič ; ić
• 关键词：Coenzyme Q₁₀ ; Vitamin E ; Antioxidant defense system ; Cadmium ; Heart ; Rats
• 刊名：Environmental Toxicology and Pharmacology
• 出版年：2006
• 出版时间：September 2006
• 年：2006
• 卷：22
• 期：2
• 页码：219-224
• 全文大小：398 K

文摘

Our study investigated the possible protective effects of coenzyme Q₁₀ (CoQ₁₀) and Vitamin E (Vit E) alone or in combination against cadmium (Cd) induced alterations of antioxidant defense system in the rat heart. Male Wistar rats were injected with a single dose of CdCl₂ (0.4 mg Cd/kg BW i.p.), CoQ₁₀ (20 mg CoQ₁₀/kg BW i.m.) and Vit E (20 IU Vit E/kg BW i.m.), alone or in combination. Acute intoxication of rats with Cd were followed by significantly increased activity of antioxidant defense enzymes (CuZn SOD, GSH-Px, GST and GR), while the activity of Mn SOD was decreased in the heart. The treatment with Cd significantly decreased Vit C and Vit E concentrations. Treatment with CoQ₁₀ and Vit E reversed Cd-induced alterations of antioxidant defense system. The obtained results support the assumption that CoQ₁₀ and Vit E functions cooperatively with endogenous antioxidants and diminished toxic effects of Cd in rat heart.