Microbial reduction of α-acetyl-γ-butyrolactone

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• 作者：Joyce Benzaquem Ribeiro ; Livia Maria Andrade de Sousa ; Mariana da Volta Soares ; Maria da Conceiç ; ã ; o Klaus V. Ramos ; Francisco Radler de Aquino Neto ; Carlos Alberto Mansour Fraga ; Selma G. Fer
• 刊名：Tetrahedron: Asymmetry
• 出版年：2006
• 出版时间：20 March 2006
• 年：2006
• 卷：17
• 期：6
• 页码：984-988
• 全文大小：231 K

文摘

Isomers of α-1′-hydroxyethyl-γ-butyrolactone can be considered as potential GHB receptor ligands designed by the molecular hybridization of GLB 2 and GHV 4. Using Aspergillus niger, Geotrichum candidum, and Kluyveromyces marxianus, it was possible to obtain (+)-(3R,1′S)-α-1′-hydroxyethyl-γ-butyrolactone in good to excellent conversions, diastereoisomeric and enantiomeric excesses. The corresponding enantiomer, (−)-(3S,1′S)-α-1′-hydroxyethyl-γ-butyrolactone was also produced in good conversion, and diastereoisomeric and enantiomeric excesses using Hansenula sp.