- 作者：K¨¢tia Wolff Cordeiro ; Lorraine Aparecida Pinto ; Anelise Samara Nazari Formagio ; S¨¦rgio Faloni de Andrade ; Candida Aparecida Leite Kassuya ; Karine de C¨¢ssia Freitas
- 关键词：Gastric ulcer ; Cerrado ; Medicinal plants ; Sangra d&rsquo ; á ; gua ; Euphorbiaceae
- 刊名：Journal of Ethnopharmacology
- 出版年：2012
- 出版时间：30 August, 2012
- 年：2012
- 卷：143
- 期：1
- 页码：331-337
- 全文大小：192 K
Ethnopharmacological relevance
Croton urucurana (Euphorbiaceae) bark is used to treat gastric ulcers. However, to our knowledge, no study has been conducted to confirm this therapeutic property.Aim of the study
To evaluate the antiulcerogenic effect and any possible toxic effects of Croton urucurana bark in an induced gastric ulcer model in rats.
Materials and methods
The preventive and healing properties of Croton urucurana bark methanol extract (CUE) were evaluated in experimental models of acute (ethanol and indomethacin) and chronic (acetic acid) gastric ulcers. The gastric juice and mucous were evaluated using the pylorus ligation model, while the gastroprotective action of sulphydryl compounds and nitric oxide were analysed using the ethanol model. The toxicity was evaluated with acute and subacute toxicity tests.
Results
No signs of toxicity were observed in the parameters analysed. All of the CUE doses tested (50, 100 and 250 mg/kg) significantly reduced the gastric lesions by 70.25, 95.40 and 98.71 % , respectively. Treatment with 30 mg/kg lansoprazole (positive control) inhibited 82.58 % of the gastric lesions. In the indomethacin model, the 50, 100 and 250 mg/kg doses of CUE significantly reduced gastric damage by 67.85, 82.50 and 71.01 % , respectively, and the positive control, cimetidine (200 mg/kg), reduced gastric damage by 91.02 % . The CUE (100 mg/kg) and cimetidine (200 mg/kg) treatments significantly reduced the ulcerative pathology induced by acetic acid, promoting 81.55 and 72.62 % healing, respectively. Nitric oxide did not change the cytoprotection generated by CUE. However, the antiulcerogenic activity of CUE appears to involve sulphydryl compounds because CUE activity was inhibited in animals receiving a sulphydryl compound blocker. In addition, CUE exhibited systemic effects, increasing mucous production and decreasing gastric acidity.
Conclusions
The present study shows that Croton urucurana bark exerts gastroprotective activity in rats without causing toxicity. This effect appears to involve sulphydryl compounds, increasing mucus production and reducing gastric acidity.