Endogenous plasma and salivary uracil to dihydrouracil ratios and DPYD genotyping as predictors of severe fluoropyrimidine toxicity in patients with gastrointestinal malignancies
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- 作者：André ; s Fernando Andrade Galarzaa ; b ; Rafael Lindenc ; Marina Venzon Antunesc ; marinaantunes@feevale.br" class="auth_mail" title="E-mail the corresponding author ; Roberta Zilles Hahnc ; Suziane Raymundoc ; Anne Caroline Cezimbra da Silvac ; Rodrigo Staggemeierc ; Fernando Rosado Spilkic ; Gilberto Schwartsmanna ; b
- 关键词：Dihydrouracil ; Uracil ; Dihydropyrimidine dehydrogenase ; DPYD ; Fluoropyrimidine ; Toxicity
- 刊名：Clinical Biochemistry
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：49
- 期：16-17
- 页码：1221-1226
- 全文大小：341 K
文摘
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The limited sensibility of DPYD genotyping significantly limits its clinical use.
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Plasma and salivary DPD tests can detect patients at risk of severe toxicity.
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Salivary [UH2]/[U] ratio performed better than plasma.
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Salivary test had 85.7% sensitivity and 76.9% specificity to predict severe toxicity.