Cholinergic enzymes and inflammatory markers in rats infected by Sporothrix schenckii
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- 作者：Veronica S.P. Castroa ; Aleksandro S. Da Silvab ; Má ; rcio M. Costac ; Francine C. Paima ; Sydney H. Alvesd ; Sonia T.A. Lopesa ; Cá ; ssia B. Silvaa ; Patrí ; cia Wolkmere ; Jorge Luiz C. Castrof ; Bianca S. Ceccoa ; Marta M.M.F. Duarteg ; Maria Rosa C. Schetingerh ; Dominguita L. Graç ; aa ; Cinthia M. Andradea ; cmelazzoandrade1@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sporotrichosis ; Acetylcholinesterase ; Cytokines ; Inflammatory markers
- 刊名：Microbial Pathogenesis
- 出版年：2016
- 出版时间：August 2016
- 年：2016
- 卷：97
- 期：Complete
- 页码：94-102
- 全文大小：1573 K
文摘
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Sporotrichosis, also known as zoonotic ringworm, is a disease of higher incidence in America.
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A dimorphic fungus Sporothrix schenckii able to promote an inflammatory response.
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Activities of AChE and BChE increased significantly in infected rats.
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The increase on cholinesterase activity leads to a reduction in acetylcholine levels, an anti-inflammatory molecule.
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Cholinesterase has an important modulatory role in the immune response during granulomatous infection by S. schenckii.