Anandamide effects on 5-HT₃ receptors in vivo

详细信息    查看全文

• 作者：Ildikó ; Rá ; cz ; Andras Bilkei-Gorzo ; Astrid Markert ; Friederike Stamer ; Manfred Gö ; thert ; Andreas Zimmer
• 关键词：Cannabinoid receptors ; 5-HT₃ receptor ; Anandamide ; Δ ; ⁹-tetrahydrocannabinol
• 刊名：European Journal of Pharmacology
• 出版年：2008
• 出版时间：31 October 2008
• 年：2008
• 卷：596
• 期：1-3
• 页码：98-101
• 全文大小：353 K

文摘

Studies in knockout mouse strains have shown that some cannabimimetic effects persist in animals lacking cannabinoid CB₁ and CB₂ receptors. These residual effects are thought to result, in part, from a cannabinoid-modulation of ion channels. This study investigates the role of 5-HT₃ receptors as a potential in vivo target for cannabinoids. Mice deficient in CB₁ and CB₂ receptors were treated with Δ⁹-tetrahydrocannabinol and anandamide, in the presence of the 5-HT₃ antagonist ondansetron. We show that the cannabinoid receptor-independent anandamide analgesia, but not catalepsy, is completely blocked by ondansetron. Thus, 5-HT₃ receptors seem to be involved in cannabinoid analgesia.