A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer
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- 作者：Bjö ; rn von Eyss1 ; Laura A. Jaenicke1 ; Roderik M. Kortlever2 ; 3 ; Nadine Royla4 ; Katrin E. Wiese1 ; Sebastian Letschert5 ; Leigh-Anne McDuffus6 ; Markus Sauer5 ; Andreas Rosenwald7 ; 8 ; Gerard I. Evan2 ; 3 ; Stefan Kempa4 ; Martin Eilers1 ; 8 ; martin.eilers@biozentrum.uni-wuerzburg.de" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2015
- 出版时间：14 December 2015
- 年：2015
- 卷：28
- 期：6
- 页码：743-757
- 全文大小：4365 K
文摘
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MYC represses YAP/TAZ-dependent transcription
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MYC-dependent changes in mitochondrial dynamics inhibit YAP/TAZ
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MYC activates AMPK downstream of changes in mitochondrial dynamics
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Activation of AMPK disrupts the TEAD-YAP interaction in MYC-driven breast cancer