Adipocyte-specific blockade of gamma-secretase, but not inhibition of Notch activity, reduces adipose insulin sensitivity
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- 作者：David P. Sparling1 ; Junjie Yu2 ; KyeongJin Kim2 ; Changyu Zhu2 ; Sebastian Brachs3 ; Andreas L. Birkenfeld4 ; 5 ; Utpal B. Pajvani2 ; up2104@cumc.columbia.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Notch ; γ-secretase complex ; Insulin resistance
- 刊名：Molecular Metabolism
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：5
- 期：2
- 页码：113-121
- 全文大小：831 K
文摘
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γ-secretase inhibitors (GSIs) are non-specific inhibitors of Notch signaling.
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GSI-treatment of obese mice increases hepatic, but lowers adipose insulin sensitivity.
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Adipocyte-specific Notch inhibition does not affect adipose mass or glucose homeostasis.
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Adipocyte-specific γ-secretase blockade reduces adipose insulin sensitivity.
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Specific Notch inhibitors may be preferable to GSIs for treatment of Type 2 Diabetes.