Neurobiological markers predicting treatment response in anxiety disorders: A systematic review and implications for clinical application
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- 作者：Ulrike Luekena ; Lueken_U@ukw.de" class="auth_mail" title="E-mail the corresponding author ; Kathrin C. Zierhuta ; Kathrin.zierhut@uni-wuerzburg.de" class="auth_mail" title="E-mail the corresponding author ; Tim Hahnb ; hahn@psych.uni-frankfurt.de" class="auth_mail" title="E-mail the corresponding author ; Benjamin Straubec ; straubeb@med.uni-marburg.de" class="auth_mail" title="E-mail the corresponding author ; Tilo Kircherc ; kircher@med.uni-marburg.de" class="auth_mail" title="E-mail the corresponding author ; Andreas Reifd ; Andreas.Reif@kgu.de" class="auth_mail" title="E-mail the corresponding author ; Jan Richtere ; Jan.Richter@uni-greifswald.de" class="auth_mail" title="E-mail the corresponding author ; Alfons Hamme ; hamm@uni-greifswald.de" class="auth_mail" title="E-mail the corresponding author ; Hans-Ulrich Wittchenf ; hans-ulrich.wittchen@tu-dresden.de" class="auth_mail" title="E-mail the corresponding author ; Katharina Domschkea ; Domschke_K@ukw.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Anxiety disorders ; Biomarker ; Treatment outcome ; Psychotherapy ; Pharmacotherapy ; SSRI ; Prediction ; Machine learning ; Genetic ; Neuroimaging ; Autonomic ; Stratified medicine
- 刊名：Neuroscience & Biobehavioral Reviews
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：66
- 期：Complete
- 页码：143-162
- 全文大小：2298 K
文摘
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Anxiety disorders are prevalent and confer a high individual & societal burden.
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Predictive biomarkers could increase response rates by patient stratification.
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Serotonin transporter genotype bears some predictive potential.
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Anterior cingulate cortex function is associated with treatment outcome.
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Large study heterogeneity reflects early phase of biomarker development.