Kinetic resolution of (±)-2-methyl-1,2,3,4-tetrahydroquinoline and (±)-2-methylindoline

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• 作者：Victor P. Krasnov ; Galina L. Levit ; Irina N. Andreeva ; Alex ; er N. Grishakov ; Valery N. Charushin ; Oleg N. Chupakhin
• 刊名：Mendeleev Communications
• 出版年：2002
• 出版时间：2002
• 年：2002
• 卷：12
• 期：1
• 页码：27-28
• 全文大小：143 K

文摘

The acylation of racemic 2-methyl-1,2,3,4-tetrahydroquinoline and 2-methylindoline by (S)-naproxen acyl chloride resulted in their kinetic resolution with the predominant formation of (S,S)-diastereoisomeric amides (de 78–76 % ), recrystallisation of which followed by acid hydrolysis gave individual (S)-isomers of heterocyclic amines.