Fast interaction between AMPA and NMDA receptors by intracellular calcium

详细信息    查看全文

• 作者：Andrei Rozov^a ; ^b ; Nail Burnashev^c ; ^d ; ^e ; ^{nail.burnashev@inserm.fr}
• 关键词：Ca2+-permeable AMPA receptor ; NMDA receptor ; Ca2+-induced inactivation ; Cross talk between receptors
• 刊名：Cell Calcium
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：60
• 期：6
• 页码：407-414
• 全文大小：1558 K
• 卷排序：60

文摘

An increase in [Ca2+]i causes a reversible Ca2+-induced inactivation of NMDAR currents. Ca2+ influx during unitary NMDAR-mediated synaptic events produces detectable self-inhibition on a time scale of a few milliseconds. Recombinant Ca2+-permeable AMPAR and Ca2+-impermeable NMDAR mutant channels were co-expressed in HEK 293 cells. The results show that Ca2+ influx through Ca2+-permeable AMPARs may inhibit NMDAR on the time scale of synaptic transmission.