Interaction of the Alzheimer Aβ(25-35) peptide segment with model membranes
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- 作者：Andreia Cucoa ; Ana Paula Serroa ; b ; José ; Paulo Farinhac ; Benilde Saramagoa ; b.saramago@tecnico.ulisboa.pt" class="auth_mail" title="E-mail the corresponding author ; Amé ; lia Gonç ; alves da Silvaa ; ameliags@tecnico.ulisboa.pt" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aβ(25&ndash ; 35) peptide ; Monolayers ; Liposomes ; Cholesterol
- 刊名：Colloids and Surfaces B: Biointerfaces
- 出版年：2016
- 出版时间：1 May 2016
- 年：2016
- 卷：141
- 期：Complete
- 页码：10-18
- 全文大小：1187 K
文摘
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Aggregation of Aβ(25–35) is not entirely prevented by HFIP and varies with pH.
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Chol slightly enhances the peptide–lipid monolayer interaction.
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Large peptide aggregates have weak interactions with lipid monolayers and liposomes.
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Peptide–lipid monolayer interaction is more efficient with small aggregates.
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Adsorbed aggregates promote penetration in the hydrophobic region of the monolayer.