Shared Genetics and Couple-Associated Environment Are Major Contributors to the Risk of Both Clinical and Self-Declared Depression

详细信息    查看全文

• 作者：Yanni Zeng ; MSc^a ; ^{Y.Zeng-6@sms.ed.ac.uk} ; Pau Navarro ; PhD^b ; Charley Xia ; MSc^b ; Carmen Amador ; PhD^b ; Ana M. Fernandez-Pujals ; MSc^a ; Pippa A. Thomson ; PhD^d ; ^e ; Archie Campbell ; MA^c ; Reka Nagy ; MSc^b ; Toni-Kim Clarke ; PhD^a ; Jonathan D. Hafferty ; MD^a ; Blair H. Smith ; MD^c ; ^f ; Lynne J. Hocking ; PhD^c ; ^g ; Sandosh Padmanabhan ; PhD^c ; ^h ; Caroline Hayward ; PhD^b ; Donald J. MacIntyre ; MD^a ; David J Porteous ; PhD^c ; ^d ; ^e ; Chris S. Haley ; PhD^b ; ⁱ ; Andrew M. McIntosh ; MD^a ; ^c ; ^d
• 关键词：Major depressive disorder ; Self-declared depression ; SNP heritability ; Couple effect ; Family environment ; Linear mixed modeling
• 刊名：EBioMedicine
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：14
• 期：Complete
• 页码：161-167
• 全文大小：519 K
• 卷排序：14

文摘

Shared genetics and couple-associated environment are major contributors to the risk of depression. The common-variant-associated genetic correlation between MDD and SDD was very high (r = 1.00, se = 0.20). Lower correlations were detected for pedigree-associated genetics and couple-shared environmental components.It is important to understand the differences between clinical depression (MDD) and self-declared depression (SDD) for which there has been recent genetics progress. We found major contributions from genetics and couple-shared environment to both traits. There is a very high correlation between the traits associated with common genetic variants but a lower correlation for other (probably rarer) genetic variation. MDD and SDD also likely differ in their shared environmental risk factors. Thus for studies of common genetic variation, SDD is a potential alternative to MDD. In clinical practice and research, the spousal depression status should also be considered a risk indicator.