Identifying Inherited and Acquired Genetic Factors Involved in Poor Stem Cell Mobilization and Donor-Derived Malignancy
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- 作者：Katarzyna Rojek1 ; Eric Nickels1 ; Barbara Neistadt1 ; Rafael Marquez1 ; Amittha Wickrema1 ; Andrew Artz1 ; Koen van Besien1 ; &dagger ; ; Richard A. Larson1 ; Ming K. Lee2 ; Jeremy P. Segal3 ; Mary-Claire King2 ; Tom Walsh2 ; Akiko Shimamura4 ; &Dagger ; ; Sioban B. Keel5 ; Jane E. Churpek1 ; 6 ; Lucy A. Godley1 ; 6 ; lgodley@medicine.bsd.uchicago.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Donor-derived leukemia ; TET2 mutation ; Clonal hematopoiesis of indeterminate potential
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：22
- 期：11
- 页码：2100-2103
- 全文大小：592 K
文摘
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Both inherited and acquired gene mutations contribute to poor mobilization of hematopoietic stem cells from HLA-matched related donors
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Identification of a donor-derived leukemia that arose from clonal hematopoiesis of indeterminate potential within a donor raises questions about the need for screening for clonal hematopoiesis of indeterminate potential within the donor pool