Ultrasound elastography: is there a shear wave speed cutoff for pediatric liver fibrosis and inflammation?

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• 作者：Andrew Phelps ; ^{Andrew.Phelps@ucsf.edu} ; Raga Ramachandran ^{Raga.Ramachandran@ucsf.edu} ; Jesse Courtier ^{Jesse.Courtier@ucsf.edu} ; Emily Perito ^{Emily.Perito@ucsf.edu} ; Philip Rosenthal ^{PRosenth@ucsf.edu} ; John D. MacKenzie ^{John.MacKenzie@ucsf.edu}
• 关键词：Elastography ; Shear wave speed ; ARFI ; pSWE
• 刊名：Clinical Imaging
• 出版年：2017
• 出版时间：January-February 2017
• 年：2017
• 卷：41
• 期：Complete
• 页码：95-100
• 全文大小：858 K
• 卷排序：41

文摘

The objective was to identify a shear wave speed (SWS) cutoff in pediatric liver disease to detect fibrosis and inflammation.MethodsWe performed an institutional-review-board-approved prospective study of liver SWS in 41 children undergoing liver biopsy.ResultsIn patients without inflammation, SWS was higher when fibrosis was present compared to when fibrosis was not present (average SWS 1.8 vs. 1.4 m/s, respectively, P=.02). A SWS cutoff of 1.7 m/s had 100% positive predictive value and 24% negative predictive value for detecting fibrosis or inflammation.ConclusionPoint shear wave elastography is an insufficient stand-alone screening tool for liver fibrosis and inflammation in a heterogeneous patient population.