Dual Targeting of PDGFRα and FGFR1 Displays Synergistic Efficacy in Malignant Rhabdoid Tumors
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- 作者：Jocelyn P. Wong1 ; 6 ; Jason R. Todd1 ; 6 ; Martina A. Finetti2 ; Frank McCarthy1 ; Malgorzata Broncel1 ; Simon Vyse1 ; Maciej T. Luczynski1 ; Stephen Crosier2 ; Karen A. Ryall3 ; Kate Holmes1 ; Leo S. Payne1 ; Frances Daley4 ; Patty Wai4 ; Andrew Jenks5 ; Barbara Tanos5 ; Aik-Choon Tan3 ; Rachael C. Natrajan4 ; Daniel Williamson2 ; Paul H. Huang1 ; 7 ; paul.huang@icr.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：signal transduction ; receptor tyrosine kinase ; rhabdoid tumor ; tyrosine kinase inhibitor ; SWI/SNF ; SMARCB1 ; PDGFRα ; FGFR1 ; pazopanib
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：25 October 2016
- 年：2016
- 卷：17
- 期：5
- 页码：1265-1275
- 全文大小：4340 K
文摘
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Malignant rhabdoid tumors display coactivation of PDGFRα and FGFR1
Dual inhibition of PDGFRα and FGFR1 leads to synergistic apoptosis
FGFR1 inhibition overcomes acquired resistance to pazopanib treatment
PDGFRα and FGFR1 are expressed in rhabdoid tumor patient specimens