Aqueous microgels modified by wedge-shaped amphiphilic molecules via acid-base interaction: Effect of alkyl chain length
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- 作者：Lei Li ; Cheng Cheng ; Marco P. Sch¨¹rings ; Xiaomin Zhu ; Andrij Pich
- 关键词：Microgel ; Drug release ; Hydrophobic domains
- 刊名：Polymer
- 出版年：2012
- 出版时间：6 July, 2012
- 年：2012
- 卷：53
- 期：15
- 页码：3117-3123
- 全文大小：859 K
文摘
We report on the synthesis and properties of aqueous poly(N-vinylcaprolactam-co-acetoacetylethylmethacrylate-co-vinylimidazole) microgels with controlled degree of hydrophobic modification. Water-insoluble wedge-shaped sulfonic acid molecules with alkyl chains of different lengths were integrated into microgels via acid-base interaction. Hydrophobized microgels retain their colloidal stability in water. The length of the alkyl chain in the wedge-shaped molecules has a significant influence on their size, loading capacity and environmental sensitivity (thermochromic effect of the dye-loaded microgels). Furthermore, the incorporation into the hydrophobized microgels of dexamethasone, an important anti-inflammatory corticoid medicine, as well as its in?vitro release profiles was investigated.