Efficient enzymatic synthesis and antibacterial activity of andrographolide glycoside
详细信息 查看全文
- 作者：Ying Qiao ; Yao Huang ; Fang Feng ; Zhi-Gang Chen ; zgchen@njau.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Andrographolide ; β ; -Galactosidase ; Glycosylation ; Regioselectivity ; Organic solvent ; Antibacterial activity
- 刊名：Process Biochemistry
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：51
- 期：5
- 页码：675-680
- 全文大小：482 K
文摘
- •
Enzymatic galactosylation of andrographolide in co-solvents was carried out.
- •
β-Galactosidase displayed high regioselectivity and stability in 5–15% DMSO–PBS.
- •
Andrographolide glycoside has higher solubility in water than andrographolide.
- •
Antibacterial activities of glycoside were higher than those of andrographolide.