Detection and characterization of clostebol sulfate metabolites in Caucasian population
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- 作者：Georgina Balcellsa ; b ; Oscar J. Pozoa ; Lorena Garrostasa ; Argitxu Esquivela ; b ; Xavier Mataboscha ; Aristotelis Kotronoulasa ; c ; Jesú ; s Joglarc ; Rosa Venturaa ; b ; rventura@imim.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Clostebol ; Sulfate metabolites ; LC&ndash ; MS/MS ; Doping analysis ; Anabolic steroid
- 刊名：Journal of Chromatography B, Analytical Technologies in the Biomedical and Life Sciences
- 出版年：2016
- 出版时间：1 June 2016
- 年：2016
- 卷：1022
- 期：Complete
- 页码：54-63
- 全文大小：1946 K
文摘
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Clostebol metabolism in man may have inter-individual and inter-ethnic variations.
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Sixteen clostebol sulfate metabolites were detected in Caucasian individuals urine.
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S1a is a long-term metabolite detectable up to 31 days after administration.
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S1a was characterized by GC–MS as 4ξ-chloro-5α-androst-3β-ol-17-one 3β-sulfate.
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Inclusion of S1a metabolite to doping control screening methods is advisable.