Androgen-metabolizing enzymes: A structural perspective
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- 作者：Mahder Seifu Manendaa ; b ; Charles Jé ; ré ; mie Hamela ; b ; Loreleï ; Masselot--Jouberta ; b ; Marie-È ; ve Picarda ; b ; Rong Shia ; b ; rong.shi@bcm.ulaval.ca" class="auth_mail" title="E-mail the corresponding author
- 关键词：3β-DIOL ; 5α-androstane-3β ; 17β-diol ; 17OHD ; 17α-hydroxylase/17 ; 20-lyase deficiency ; 20 ; 22-DHC ; 20 ; 22-dihydroxycholesterol ; 20-HC ; 20-hydroxycholesterol ; 22-HC ; 22-hydroxycholesterol ; ABAD ; amyloid beta-binding alcohol dehydrogenase ; AcO- ; acetate ; Adx ; adrenodoxin ; AI ; aromatase inhibitor ; AKR ; aldo/keto reductase ; ANZ ; anastrozole ; AR ; androgen receptor ; AEXS ; aromatase excess syndrome ; AROD ; aromatase deficiency ; ASD ; androstenedione or androst-4-ene-3 ; 17-dione ; CPR ; cytochrome P450 reductase
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：161
- 期：Complete
- 页码：54-72
- 全文大小：5191 K
文摘
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Known structures of androgen metabolizing enzymes are reviewed.
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Structural analysis of enzyme-ligand complexes are included.
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Structural insights used in inhibitor design are discussed.