Laccase-mediated oxyfunctionalization of 3β-hydroxy-Δ5-steroids
详细信息 查看全文
- 作者：Sergey M. Khomutov ; skhomutov@rambler.ru" class="auth_mail" title="E-mail the corresponding author ; khom@ibpm.pushchino.ru" class="auth_mail" title="E-mail the corresponding author ; Andrey A. Shutov ; Alexey M. Chernikh ; Nina M. Myasoedova ; Ludmila A. Golovleva ; Marina V. Donova
- 关键词：Laccase ; Steroid ; Oxidation ; Laccase mediator system ; Dehydroepiandrosterone ; Pregnenolone ; Oxyfunctionalization
- 刊名：Journal of Molecular Catalysis B: Enzymatic
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：123
- 期：Complete
- 页码：47-52
- 全文大小：891 K
文摘
- •
Fungal laccases were tested in bioconversion of non-phenolic steroids.
- •
Laccase-mediated systems effectively catalyze oxidation of 3β-hydroxy-Δ5-steroids.
- •
The oxidation of 3β-hydroxyandrost-5-en-17-one includes the hydroxylation at positions 7α and 7β.
- •
Regiospecific oxidation of the 7(α/β)-alcohols results in 3β-hydroxy-androst-5-en-7,17-dione.
- •
3β-Hydroxypregn-5-ene-7,20-dione is an only laccase product from pregnenolone.