Optically active stereoisomers of 5-(1-iodoethyl)-4-(4′-isopropylphenyl)dihydrofuran-2-one: The effect of the configuration of stereocenters on apoptosis induction in canine cancer cell lines

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• 作者：Aleksandra Pawlak^a ; ^{aleksandra.pawlak@up.wroc.pl} ; Witold Gładkowski^b ; ^{glado@poczta.fm} ; Marcelina Mazur^b ; ^{marcelina.mazur@up.wroc.pl} ; Marta Henklewska^a ; ^{marta.henklewska@up.wroc.pl} ; Bożena Obmińska-Mrukowicz^a ; ^{b.mrukowicz@gmail.com} ; Andrzej Rapak^c ; ^{rapak@iitd.pan.wroc.pl}
• 关键词：Structure&ndash ; activity relationship ; β-Aryl-δ-iodo-γ-lactones ; Apoptosis ; Canine cancers ; Canine cancer cell lines
• 刊名：Chemico-Biological Interactions
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：261
• 期：Complete
• 页码：18-26
• 全文大小：1665 K
• 卷排序：261

文摘

Stereoisomers of δ-iodo-γ-lactones induced apoptosis of canine cancer cells. Observed apoptosis occur via a mitochondrial-mediated, caspase-dependent pathway. Configuration of stereogenic centers affect anticancer activity of tested lactones. Activity was higher against canine lymphoma/leukemia than mammary tumor cell lines.