Biological evaluation of new vitamin D2 analogues
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- 作者：Aoife Corcorana ; Maria A. Bermudezb ; Samuel Seoaneb ; Roman Perez-Fernandezb ; Małgorzata Krupac ; Anita Pietraszekc ; Michał Chodyńskic ; Andrzej Kutnerc ; Geoffrey. Brownd ; Ewa Marcinkowskaa ; ema@cs.uni.wroc.pl" class="auth_mail" title="E-mail the corresponding author
- 关键词：vitamin D analogues ; vitamin D receptor ; Leukemia ; Differentiation ; Calcemic effects ; Keratinocytes
- 刊名：Journal of Steroid Biochemistry and Molecular Biology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：164
- 期：Complete
- 页码：66-71
- 全文大小：1108 K
文摘
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We examined activity profiles of double-point modified analogues of vitamin D2.
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The analogues were less toxic in vivo than 1,25D.
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Pro-differentiating activities of analogues were stronger than that of 1,25D.
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The analogues upregulated expression of CYP24A1 and CD14 stronger than 1,25D.
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Neither calcemic, nor pro-differentiation effects were correlated to VDR binding.