Screening of circulating microRNA biomarkers for prevalence of abdominal aortic aneurysm and aneurysm growth

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• 作者：Anders Wanhainen^a ; Kevin Mani^a ; Emina Vorkapic^b ; Rachel De Basso^c ; ^d ; Martin Bjö ; rck^a ; Toste Lä ; nne^e ; Dick Wå ; gsä ; ter^b ; ^{Dick.Wagsater@liu.se}
• 关键词：Biomarker ; Plasma ; Risk factor ; Aneurysm ; MicroRNA
• 刊名：Atherosclerosis
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：256
• 期：Complete
• 页码：82-88
• 全文大小：373 K
• 卷排序：256

文摘

MiRs are regulators of gene expression and biological processes and have recently been suggested as possible biomarkers for abdominal aortic aneurysm (AAA) disease. We were able to identify several novel miRs found to be altered between AAA and controls. By combining several miRs with clinical covariates, we could further distinguish slow growing from fast growing AAA. Novel genes previously not linked to AAA are highlighted and deserve a focus in future studies.