Leishmania major and Trypanosoma cruzi present distinct DNA damage responses
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- 作者：Juliana B.F. Garciaa ; 1 ; julianaborio@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Joã ; o P.Vieira da Rochab ; 1 ; joaopvr@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Hé ; llida M. Costa-Silvab ; hellidamarina@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Ceres L. Alvesb ; ceres_luciana@yahoo.com.br" class="auth_mail" title="E-mail the corresponding author ; Carlos R. Machadob ; crmachad@icb.ufmg.br" class="auth_mail" title="E-mail the corresponding author ; Angela K. Cruza ; akcruz@fmrp.usp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：Leishmania major ; Trypanosoma cruzi ; DNA damage response ; Anti-silencing factor 1 ; Methyl methanesulfonate ; Gamma irradiation
- 刊名：Molecular & Biochemical Parasitology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：207
- 期：1
- 页码：23-32
- 全文大小：2870 K
文摘
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T. cruzi efficiently repair double-strand breaks in DNA.
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L. major presents higher radiosensitivity than T. cruzi.
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L. major exhibits higher resistance to alkylating DNA damage.
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Overexpression of ASF1c in both parasites delayed cell fate after damage induction.